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SynBioControl

Design, characterization and optimal tuning of synthetic biocircuits for bioproduction with metabolic load control.

Field
National
Date
01/01/2018 - 31/12/2020
Industry
  • Industry
Budget
Funded by

R+D+I Challenges Project. State Plan for Scientific and Technical Research and Innovation 2013-2016. Ministry of Science, Innovation and Universities

Website
Video

PROJECT INFORMATION

DESCRIPTION

The project focuses on one practical challenge and two related general objectives: General Practical Challenge: Design and implementation of feedback control mechanisms for protein and metabolite expression with consideration of the effects of genetic and metabolic load. Methodological Objective 1: Development of methods for structural design, analysis and robust parametric adjustment of synthetic genetic control circuits through multiobjective optimization. Methodological Objective 2: Development of data analytics methods and grey models with application to scale-up from the laboratory to the pre-industrial bioreactor.

The project focuses on one practical challenge and two related general objectives: General Practical Challenge: Design and implementation of feedback control mechanisms for protein and metabolite expression with consideration of the effects of genetic and metabolic load. Methodological Objective 1: Development of methods for structural design, analysis and robust parametric adjustment of synthetic genetic control circuits through multiobjective optimization. Methodological Objective 2: Development of data analytics methods and grey models with application to scale-up from the laboratory to the pre-industrial bioreactor.

Contact information

Picó Marco, Jesús Andrés
Catedrático/a de Universidad - PDI

Ai2

Technological capabilities

Big Data
Data analysis and exploitation